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| Daniel J. Uhlrich
Professor
Department of Anatomy
251 Bardeen
Office Phone: 608/262-8465
Lab Phone: 608/262-8466
Fax: 608/262-7306
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Website |
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duhlrich@facstaff.wisc.edu |
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Research Description
Neural Modulation of Visual Signals in the Thalamus; Photosensitive Epilepsy
The thalamus is the location where ascending visual signals destined for cerebral cortex for perception can be modified as a function of behavioral states. The thalamus also acts as an intermediary for cortico-cortical communication. Our research aims to understand the anatomical and electrophysiological bases of these processes using neuroanatomical and immunohistochemical light and electron microscopic methods and single- and multi-unit electrophysiological recordings with activation of specific neuromodulatory projections.
Thalamo-cortical neural circuitry is also involved in the generation of normal brain rhythms that occur across the sleep wake cycle and in the pathological rhythms of absence (petit mal) epilepsy. Absence seizures can be triggered by flashing visual stimuli, and we are studying the thalamic mechanisms that lead to the onset of these phototriggered seizures.
Recent Publications
Uhlrich, D.J., K.A. Manning, and J.-T. Xue (2002) Effects of activation of the histaminergic tuberomammillary nucleus on visual responses of neurons in the dorsal lateral geniculate nucleus. J. Neuroscience. 22:1098-1107.
Briska, A.M., D.J. Uhlrich, and W.W. Lytton (2000) Independent dendritic domains in the thalamic circuit. Neurocomputing 32-33: 299-305.
Lord Plummer, K., K.A. Manning, A.I. Levey, H.D. Rees, and D.J. Uhlrich (1999) Muscarinic receptor subtypes in the lateral geniculate nucleus: A light and electron microscopic analysis. J. Comp. Neurol. 404: 408-425.
Zhu, J.J., W.W. Lytton, J-T. Xue, and D.J. Uhlrich (1999) An intrinsic oscillation in interneurons of the rat lateral geniculate nucleus. J. Neurophysiol. 81: 702-711.
Zhu, J.J. and D.J. Uhlrich (1997) Nicotinic receptor-mediated responses in relay cells and interneurons in the rat lateral geniculate nucleus. Neuroscience 80: 191-202. |
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