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| Lewis Haberly
Professor
Department of Anatomy
147 Bardeen Labs
Office Phone: 608/262-7918
Lab Phone: 608/262-1607
Fax: 608/262-7306
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lhaberly@facstaff.wisc.edu |
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Research Description
Analysis of the operation of neuronal circuitry in cerebral cortex.
My research is concentrated in 2 areas: learning and memory, and epilepsy. A variety of physiological and anatomical approaches are used including patch recording in brain slices from neurons visualized with Nomarski optics, impalement of neurons with microelectrodes in anesthetized rats for combined anatomical-physiological analysis, visualization of spatial patterns of neuronal activity by immunocytochemically detecting activity-induced gene expression, and recording of neuronal activity in behaving rats with implanted electrodes.
In our studies of learning and memory we are exploring Ôcontent addressable memoryÕ processes in the cerebral cortex similar to those being developed for artificial neural networks. Ongoing research includes studies of neuronal connectivity, physiological analysis of synaptic plasticity, study of the ensemble coding of sensory information, and analysis of functional roles of fast EEG rhythms. Our studies of epileptogenesis are currently focusing on neuronal mechanisms that underlie the spread of seizures into normal cortex from focal areas of origin.
Recent Publications
Kanter ED, Kapur A, and Haberly LB (1996) A dendritic GABAA-mediated IPSP regulates facilitation of NMDA-mediated responses to burst stimulation in piriform cortex. J Neurosci 16:307-312.
Johnson DMG, Illig KR, Behan M, Haberly LB (2000) New features of connectivity in piriform cortex visualized by intracellular injection of pyramidal cells suggest that ÔprimaryÕ olfactory cortex functions like ÔassociationÕ cortex in other sensory systems. J Neurosci 20:6974-6982.
Ekstrand JJ, Domroese ME, Johnson DMG, Feig SL, Knodel SM, Behan M, Haberly LB (2001). A new subdivision of anterior piriform cortex and associated deep nucleus with novel features of interest for olfaction and epilepsy. J Comp Neurol 434:289-307.
Haberly LB (2001) Parallel-distributed processing in olfactory cortex: new insights from morphological and physiological analysis of neuronal circuitry Chem Senses 26:551-576.
Short Review
Haberly LB, Bower JM (1989) Olfactory cortex: model circuit for study of associative memory? Trends Neurosci. 12: 258-264.
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