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| Yevgenya Grinblat
Assistant Professor
Departments of Anatomy and Zoology
129 Zoology Research
Office Phone: 608 265-3219
Lab Phone: 608 265-3250
Fax: n/a
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ygrinblat@facstaff.wisc.edu |
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Research Description
Patterning and morphogenesis of the neural tube in zebrafish
The primary focus of my lab is on the study of pattern formation and morphogenesis in the developing vertebrate brain. The future brain is patterned along two of the body's primary axes, anteroposterior and dorsal-ventral, very early during embryogenesis, prior to neural tube formation and well before onset of neurogenesis. We are particularly interested in understanding how early pattern forms at the border of the neural plate, which later becomes the dorsal-most neural tube. We use a model organism, the zebrafish Danio rerio, to address these fundamental aspects of early neural development using a combination of genetics, embryology and molecular biology. Our specific approach includes (1) Detailed description of the fine pattern of gene expression near the border of the neural plate; (2) Analysis of the role known signaling molecules, eg. BMP and FGF pathways, play during formation of pattern at the neural plate border; (3) Promoter analysis of tissue-specific gene regulation; (4) Mutant screening to identify novel regulators of neural tube patterning and morphogenesis. We anticipate that our findings will advance understanding of early neural development in higher vertebrates.
Recent Publications
Y. Grinblat, H.L. Sive (2001) zic gene expression marks anteroposterior pattern in the presumptive neurectoderm of the zebrafish gastrula. Dev. Dynamics 222, 688-693.
Y. Grinblat, M. E. Lane, C. G. Sagerstršm andy">m and H. L. Sive (1999). Analysis of Zebrafish development using explant culture assays. In The Zebrafish: Methods in Cell Biology, vol. 59 (ed. H. W. Dietrich, M. Westerfield and L. Zon). pp. 127-159. San Diego: Academic Press.
Y. Grinblat, J. T. Gamse, M. Patel and H. L. Sive (1998). Determination of the zebrafish forebrain: induction and patterning. Development 125: 4403-4416.
C. Sagerstrom, Y. Grinblat, H.L.Sive. (1996) Anteroposterior patterning in the zebrafish, Danio rerio: an explant assay reveals inductive and suppressive cell interactions. Development 122: 1873-1883. |
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